He is known for his collaboration with chamber music groups and other musicians, such as Borodin and Glinka Quartets, National Symphony Orchestra in Russia, Thomas Sanderling, Tugan Sokhiev, Alexandr Chernushenko, Valeriy Polyansky, Mikhail Agrest, Pascal Moragues, Julius Milkis, Evgeny Petrov, Pavel Kogan, Abel Perreira, Benjamin Schmid, Stepan Yakovich, Ani Kavafian, Andrei Gridchuk, Alena Baeva, Zlatomir Fung, Filip Kopachevsky, Yana Ivanilova, Nina Kogan, Mikhail Bereznitsky, Maxim Emelyanychev, Diana Vishneva, Philippe Cassard, Alexandre Lazarev, Gaik Kazazyan, Lukas Geniushas, Richard Young, Valentin Uriupin, Itamar Zorman, and many others. He has recorded numerous disks with compositions of Chopin, Schumann, Schubert, Brahms, Tchaikovsky, Beethoven, Shostakovich, and he has given masterclasses in the USA, Russia, Estonia, Kazakhstan, Ireland, Germany, Spain, Italy, Korea, Brazil, and Japan.

In 2005 he became a merited artist of the Russian Federation.

For more than 25 years P. Nersessian has been assisting his teacher, professor S. Dorensky. He has worked with such talented pupils as N. Lugansky, D. Matsuev, V. Rudenko, O. Kern, A. Shtarkman, Yu. Stadler, I. Tasovats, F. Amirov, M. Amara, A. Dossin, V. Igoshina, A. Mamriev, V. Korchinskaya-Kogan, S. Simonian, Z. Chochieva, G. Chaidze, N. Pisareva, A. Sychev, F. Kopachevsky, P. Kolesnikov, A. Tarasevich-Nikolaev, L. Bernsdorf, P. Elisha, A. Malofeev, A, Kliuchko and many others.

Pavel Nersessian served as a jury member in many international piano competitions: Dublin, Hamamatsu, Sendai, Maria Canals in Barcelona, Hilton Head, Almaty, Valencia, Tbilisi and other competitions.

In 2013 he started to work as a professor of piano in Boston university, in 2022 as a professor of piano in New England Conservatory.

Recent recitals of Pavel Nersessian include chamber programs with violinists Kirsti Kuusk, Garry Levinson, Daniil Kogan as well as singers Ilya Silchukou and Julia Lezhneva.